Background: Lateral epicondylitis is common and may negatively impact activities of daily living.
Currently, various conservative treatments are available including physiotherapy, pharmacotherapy, and
interventional physiatry. Among the interventional procedures, periarticular hyaluronic acid (HA)
the injection is an emerging treatment option, but it lacks firm evidence to support its use.
Objective: The objective of the study was to determine the effectiveness and safety of HA in reducing
pain and improving the function of patients with lateral epicondylitis. Methods: We conducted a systematic review in January 2020. Randomized controlled trials identified from various electronic databases were included if they involved the following: Adults with lateral epicondylitis, periarticular injection of HA with or without other medications, and reported outcomes on pain, function, and adverse effects. Assessment of risk of bias was performed using the Cochrane Collaboration Tool. Pertinent data were extracted from the eligible studies for data analysis.
